Penicillin

The Penicillin is a smoky-sweet modern classic that bridges the warmth of Scotch with the brightness of fresh citrus and the soothing kick of honey and ginger. First created in the early 2000s, this cocktail delivers bold character while remaining accessible and well-rounded. A float of peaty Islay Scotch on top adds a distinctive aromatic layer without overpowering the drink. It’s a smart choice for anyone who enjoys complex flavor profiles without fuss. Ideal for cooler evenings or as a thoughtful sipper at any time of year.

Tasting Notes

The Penicillin offers a warming and balanced blend of smoke, citrus, and spice. Blended Scotch provides a mellow foundation, while lemon juice brings brightness and acidity. The honey-ginger syrup adds gentle sweetness with a spicy edge. Topped with a float of peaty Islay Scotch, each sip begins with bold smoke and finishes with soothing warmth. The cocktail has a full-bodied texture, lifted by citrus and softened by honey. Its flavor unfolds slowly over ice, evolving as the drink dilutes. Rich but approachable, it’s ideal for cool evenings or moments when you want something both strong and smooth.

Equipment and Glassware

To make a Penicillin cocktail, you’ll need a cocktail shaker for mixing, along with a jigger or measuring tool to ensure accuracy. A citrus press or juicer helps extract fresh lemon juice, while a fine mesh strainer or Hawthorne strainer keeps the pour clean. A bar spoon is useful for floating the Islay Scotch on top of the drink. Use a rocks glass or old-fashioned glass for serving. Ice cubes preferably large format are essential for chilling without over-dilution. For garnish, have a small knife or peeler ready to prepare a lemon twist or skewer a piece of candied ginger.

Ingredients

• 2 oz Blended Scotch Whisky
• 3/4 oz Fresh lemon juice
• 3/4 oz Honey-ginger syrup
• 1/4 oz Islay Single Malt Scotch
• Garnish: Candied ginger or lemon twist

Instructions

• In a cocktail shaker, combine the blended Scotch, lemon juice, and honey-ginger syrup.
• Fill the shaker with ice and shake well until it’s very cold.
• Strain the mixture into a rocks glass filled with ice.
• Float the Islay Scotch on top by pouring it over the back of a spoon.
• Garnish with a piece of candied ginger or a lemon twist.

Pro Tips

• Use fresh lemon juice for best results
• Make honey-ginger syrup ahead: 1:1 honey, water, and sliced ginger
• Shake hard to fully blend the syrup and lemon
• Float the Islay Scotch gently to keep the layers distinct
• Large ice cubes help slow dilution
• Choose a blended Scotch with mild peat or fruit notes
• For less smoke, reduce the Islay Scotch to a few drops
• Let the drink sit briefly for flavors to open
• Store honey syrup in the fridge for up to a week
• Use a citrus peel instead of a twist for stronger oils

When to Serve

The Penicillin is best suited for cooler months or evenings when a richer, warming cocktail fits the mood. It’s a great choice for after-dinner sipping or paired with hearty food like roasted meats or grilled vegetables. It also works well as a winter happy hour option or for cozy indoor gatherings. The balance of sweet, sour, and smoke makes it versatile enough for casual or more refined settings. Serve it over ice in a rocks glass when you’re in the mood for something flavorful, strong, and layered in character.

Which Liquor Brands to Choose 

Blended Scotch Whisky:

• Monkey Shoulder
• Johnnie Walker Black Label
• Chivas Regal 12
• Dewar’s White Label
• Famous Grouse

Islay Single Malt Scotch:

• Caol Ila 12
• Laphroaig 10
• Ardbeg 10
• Lagavulin 8 or 16
• Bowmore 12

Similar Cocktails

• Ginger Ale Highball
• Whiskey Sour
• The Gold Rush
• Honey Ginger French 75
• Berry Beer